Epicardial Pulsed Field Ablation of Ganglionated Plexi: Computational and Pre-Clinical Evaluation of a Bipolar Sub-Xiphoid Catheter for the Treatment of Atrial Fibrillation

Pre-Clinical
B O’Brien, J Reilly, K Coffey et al
Bioengineering 2024.

This paper presents electric field models and ablation studies for the prototype bipolar and subxiphoid device – both porcine and canine models were used. Acute extensions in atrial effective refractory period suggest that ablations efficacy is at least equivalent to the monopolar device that has already been used in open-chest clinical settings. Ablation of neuronal cells, within the epicardial ganglionated plexi, was confirmed through histology.