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Novel Percutaneous Epicardial Autonomic Modulation in the Canine for Atrial Fibrillation: Results of an Efficacy and Safety Study

Pre-ClinicalM Madhavan, KL Venkatachalam, MJ Swale et alPacing Clin Electrophysiol 2016. This was the first screening study at Mayo Clinic to assess the best energy source for ablation of ganglionated plexi, while minimizing myocardial damage. Following selection of...

Electroporation of epicardial autonomic ganglia: Safety and efficacy in medium‐term canine models

Pre-ClinicalD Padmanabhan, N Naksuk, AK Killu et alJ Cardiovasc Electrophysiol 2019. This study was performed using sub-xiphoid access with acute measurements showing that ganglionated plexi ablation produced an extension in the atrial effective refractory period...

Open-chest Pulsed Electric Field Ablation of Cardiac Ganglionated Plexi in Acute Canine Models

Pre-ClinicalM van Zyl, M Khabsa, JA Tri et alJ Innov Cardiac Rhythm Manage 2022. This open-chest study was performed as full system validation before progressing to first-in-human open-chest clinical trials. It’s utilized AtriAN’s cardiac-customized pulsed field...

Safety and Feasibility of Epicardial Percutaneous Access and Maneuverability With a Novel Ablation Catheter for the Treatment of Atrial Fibrillation in a Porcine Model

Pre-ClinicalP Buszman, K Lukasik, S Deane et alJ Am Coll Cardiol 2021 (Supplement). This was a first feasibility of epicardial access using the initial prototype of a next generation catheter system designed for sub-xiphoid access and with bipolar ablation capability....

Establishing Irreversible Electroporation Electric Field Potential Threshold in A Suspension In Vitro Model for Cardiac and Neuronal Cells

In-Vitro StudiesS Avazzadeh, B O’Brien, K Coffey et alJournal of Clinical Medicine 2021 This in-vitro cellular study explored the electroporation thresholds of neurons and cardiomyocytes in suspension. This is the first published data showing that the thresholds for...
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Recent Posts

  • Novel Percutaneous Epicardial Autonomic Modulation in the Canine for Atrial Fibrillation: Results of an Efficacy and Safety Study
  • Electroporation of epicardial autonomic ganglia: Safety and efficacy in medium‐term canine models
  • Open-chest Pulsed Electric Field Ablation of Cardiac Ganglionated Plexi in Acute Canine Models
  • Safety and Feasibility of Epicardial Percutaneous Access and Maneuverability With a Novel Ablation Catheter for the Treatment of Atrial Fibrillation in a Porcine Model
  • Establishing Irreversible Electroporation Electric Field Potential Threshold in A Suspension In Vitro Model for Cardiac and Neuronal Cells

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