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Targeted ablation of epicardial ganglionated plexi during cardiac surgery with pulsed field electroporation (NEURAL AF)

DR Musikantow, VY Reddy, I Skalsky et al
J Interv Card Electrophysiol 2023.
AtriAN’s first-in-human safety and feasibility study is presented in this article. Ganglionated plexi (GP) were ablated in 24 patients undergoing concomitant open-chest coronary artery bypass grafting (CABG). There was no study-related complications and all GP sites were successfully treated. A 20% acute extension in atrial effective refractory period was recorded.

Novel Percutaneous Epicardial Autonomic Modulation in the Canine for Atrial Fibrillation: Results of an Efficacy and Safety Study

M Madhavan, KL Venkatachalam, MJ Swale et al
Pacing Clin Electrophysiol 2016.

This was the first screening study at Mayo Clinic to assess the best energy source for ablation of ganglionated plexi, while minimizing myocardial damage. Following selection of pulsed field ablation (PFA) from the screening work, procedural feasibility was also demonstrated in both open-chest and sub-xiphoid models, using early prototype devices.