Articles
Publications
Reach out to us for your interest in our technology
Targeted ablation of epicardial ganglionated plexi during cardiac surgery with pulsed field electroporation (NEURAL AF)
Clinical
DR Musikantow, VY Reddy, I Skalsky et al
J Interv Card Electrophysiol 2023.
DR Musikantow, VY Reddy, I Skalsky et al
J Interv Card Electrophysiol 2023.
AtriAN’s first-in-human safety and feasibility study is presented in this article. Ganglionated plexi (GP) were ablated in 24 patients undergoing concomitant open-chest coronary artery bypass grafting (CABG). There was no study-related complications and all GP sites were successfully treated. A 20% acute extension in atrial effective refractory period was recorded.
Cardioneuroablation Using Epicardial Pulsed Field Ablation for the Treatment of Atrial Fibrillation
Review
B O’Brien, J Reilly, K Coffey et al
J. Cardiovasc. Dev. Dis. 2023.
B O’Brien, J Reilly, K Coffey et al
J. Cardiovasc. Dev. Dis. 2023.
The background and development of cardioneuroablation techniques are presented in the context of AtriAN’s therapy. An overview of key work is presented, covering in vitro studies, electric field models, pre-clinical research and clinical trials. Future work and applications are discussed.
Novel Percutaneous Epicardial Autonomic Modulation in the Canine for Atrial Fibrillation: Results of an Efficacy and Safety Study
Pre-Clinical
M Madhavan, KL Venkatachalam, MJ Swale et al
Pacing Clin Electrophysiol 2016.
This was the first screening study at Mayo Clinic to assess the best energy source for ablation of ganglionated plexi, while minimizing myocardial damage. Following selection of pulsed field ablation (PFA) from the screening work, procedural feasibility was also demonstrated in both open-chest and sub-xiphoid models, using early prototype devices.